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    • Amphiphilic Rhenium-Oxo Corroles as a New Class of Sensitizers for Photodynamic Therapy 

      Einrem, Rune F.; Alemayehu, Abraham; Borisov, Sergey M.; Ghosh, Abhik; Gederaas, Odrun Arna (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-27)
      A set of rhenium(V)-oxo <i>meso</i>-triarylcorroles bearing ester and carboxylic acid functionalities were synthesized with a view to determining their potential for photodynamic therapy. Toward this end, we measured their near-IR phosphorescence and their ability to sensitize singlet oxygen formation. The two esters studied, Re<sup>V</sup>O 5,10,15-tris(<i>meta</i>-carbomethoxyphenyl)corrole and ...

    • Homology Modeling of Human <gamma>-Butyric Acid Transporters and the Binding of Pro-drugs 5-Aminolevulinic Acid and Methyl Aminolevulinic Acid used in Photodynamic Therapy 

      Baglo, Yan; Gabrielsen, Mari; Sylte, Ingebrigt; Gederaas, Odrun Arna (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Photodynamic therapy (PDT) is a safe and effective method currently used in the treatment of skin cancer. In ALA-based PDT, 5-aminolevulinic acid (ALA), or ALA esters, are used as pro-drugs to induce the formation of the potent photosensitizer protoporphyrin IX (PpIX). Activation of PpIX by light causes the formation of reactive oxygen species (ROS) and toxic responses. Studies have indicated that ...